梅内·潘加罗斯教授
公司高级管理团队的一员, Mene has overall responsibility for the company’s pharmaceutical discovery research and early development activities.
自2010年加入澳门葡京网赌游戏以来, Mene has been instrumental in rebuilding the company’s commitment to science and scientific excellence. 他领导了R的转型&D productivity, 推动与学术界更深入的合作, 生物科技及同类机构, pioneered programmes to promote 开放创新 and fostered a science driven culture that rewards great science and truth-seeking behaviours.
Mene retains an active interest in neurodegenerative disease and neuropharmacology and continues to mentor post docs and PhD students.
Mene has published more than 150 peer-reviewed articles in scientific journals and is an internationally renowned expert in neuroscience and drug discovery. 他是英国科学界的领军人物，在多个董事会任职，包括英国皇家科学院 弗朗西斯·克里克研究所剑桥大学 贾奇商学院 and Dizal Pharma. 梅内被选为 Royal Society 他也是他们的一员 科学、工业和翻译委员会，并与 医学科学院, the 英国皇家生物学会 and 克莱尔·霍尔-剑桥大学. 他是议会的成员 医学研究委员会(MRC), 生命科学理事会创新专家组联合主席, Clinical Research and Data and is a member of the UK Life Sciences Industrial Strategy Implementation Board. Mene was recognised in the New Year 2020 Honours list with a knighthood from Her Majesty The Queen of United Kingdom of Great Britain and Northern Ireland, 表彰他对英国科学的贡献.
梅内负责澳门葡京网赌游戏新R&D Centre in Cambridge – a state of the art facility designed to stimulate collaborative scientific innovation and which will play an important role in the future success of the UK life science industry.
Our commitment is clear – fostering a culture that rewards pioneering science and asks the ‘killer’ questions. 这就是澳门葡京赌博游戏如何突破可能的界限.
CURRENT ROLE
AWARDED
TRANSFORMING R&D
CREATING NEW R&D CENTRE
开创性的举措
特色的出版物
GABA
The GABAB2 subunit is essential for G protein coupling of the GABAB receptor heterodimer.
Robbins MJ, Calver AR, Fillipov AK, Couve A, Moss SJ和Pangalos MN. J. 神经科学(2001)21:8043-8052.
http://www.jneurosci.org/content/21/20/8043.full.pdf
A role for cAMP dependent protein kinase phosphorylation in facilitating GABAB receptor effector coupling Nature Neuroscience (2002)
cove A, Thomas P, Calver A, Hirst WD, Pangalos MN, Walsh FW, Smart T和Moss SJ. 5: 1-10.
http://www.nature.com/neuro/journal/v5/n5/full/nn833.html
Phospho-dependent functional modulation of GABAB receptors by the metabolic sensor AMP-dependent protein kinase. Neuron.
Kuramoto N, Wilkins M, Fairfax B, Revilla-Sanchez R, Tamaki K, Couve A, Calver AR, Horvath Z, Freeman K, Carling D, Huang L, Cooper E, Gonlazes C, Cooper E, Smart TG, Pangalos MN, Moss SJ. (2007) 53:233-247.
http://www.cell.com/neuron/abstract/S0896-6273(06)01020-8
Prolonged activation of NMDA receptors induces dephosphorylation and degradation of GABAB receptors.
Terunuma M, Vargas KJ, Wilkins ME, Ramirez OA, Pangalos MN, Smart TG, Moss SJ and Couve A. Pnas, 2010, 107(31):13918-23.
http://www.pnas.org/content/107/31/13918.full
Postsynaptic GABAB Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory.
Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN和Moss SJ. 神经科学杂志，2014,34:804-816.
http://www.jneurosci.org/content/34/3/804.full.pdf
阿尔茨海默病
Early-onset behavioral and synaptic deficits in a mouse model of 阿尔茨海默病.
Jacobsen JS, Wu C-C, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH和Bloom FE. 中国科学院学报，2006,31 (3):561 - 566.
http://www.pnas.org/content/103/13/516
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
Jacobsen SJ, Comery TA, Marton RL, Elkodah H, Crandall DL, Oganesian A, Aschmies S, Kirksey Y, Gonzalez C, Xu J, Zaleska MM, Das I, Arias RL, Bard J, Riddell D, Gardell SJ, Abou-Gharbia米, Robichaud A, Magolda R, Vlasuk GP, Bjornsson T, Reinhart PH, Pangalos MN. 中国科学院院刊，2008,25 (5):874 - 879.
http://www.pnas.org/content/105/25/8754.ful
载脂蛋白E (ApoE)多态性对脑ApoE水平的影响.
Riddell DR, Kirksey Y, Hu Y, Warwick HK, Li Zhutting, Zhou H, Jacobsen JS, Pangalos MN和Reinhart PH和J神经科学. (2008) 28(45):11445-11453.
http://www.jneurosci.org/content/28/45/11445.full.pdf
淀粉样蛋白治疗阿尔茨海默病. In The Biology of Alzheimer’s Disease, edited by Holtzman D, Mandelkow E and Selkoe D
Basi G, Pangalos MN和Schenk D. (2012) 423-454.
R&D Productivity
该怎么做? “Translational Neuroscience: Toward New Therapies” Strüngmann Forum Reports Series
Holtzman DM, Nikolich K, Pangalos MN, Broich K, Ip NY, Koo EH, Koroshetz WJ, Masliah E, Mucke L, Nicotera P, Schnaars M, Spillantini毫克. Neurodegenerative Diseases; ed. J. Lupp. 剑桥，麻省理工学院出版社(2015).
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. 自然药物发现
Cooke D, Brown D, Alexander R, March R, Morgan P, Satterthwaite G和Pangalos MN. (2014) 13, 419–431.
http://www.nature.com/nrd/journal/v13/n6/full/nrd4309.html
Pioneering Government-Sponsored, Collaborative Drug Repositioning Initiatives: Progress and Learning. 药物发现
Frail D, Wegner C, Sanganee H, Brady M, Escott J, Pangalos MN, Holt A and Watkins C. (2015) in press.
Honours
Honours
Award
Our people share a common purpose: to push the boundaries of science to deliver life-changing medicines.
澳门葡京赌博游戏是全球性的, science-led biopharmaceutical business and our innovative medicines are used by millions of patients worldwide.
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并帮助澳门葡京赌博游戏提供改变生活的药物
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